Cancer Research UK Cambridge Institute

The Cancer Signaling and Therapeutics Lab (https://creixell-lab.com/), led by Group Leader Dr Pau Creixell, is part of the University of Cambridge - Cambridge Institute (CI) (http://www.cruk.cam.ac.uk/), the world class institute situated on the Cambridge Biomedical Campus in Cambridge, UK, and created by a collaboration between Cancer Research UK, Europe's top cancer charity, with the University of Cambridge.

A postdoctoral position is currently available in our lab for a highly talented and motivated individual interested in developing and using our technologies, particularly peptide display, to screen tyrosine and serine protein kinases with the aim to eventually target them better. The aim would be to use the peptides as a template of how to target these kinases using small molecules. Our lab is currently developing technology that allows the screening and computational interpretation of combinatorially complete libraries of mutant protein variants. We are interested in further developing and deploying these technologies in applications ranging from signaling and therapeutics. This position is funded through the Brain Tumour Charity and is in collaboration with Professor Bill Weiss (UCSF) and Professor Kevan Shokat (UCSF) who will collaborate with their expertise in the follow-on stage of the initial peptide screening.

Applicants must have received (or be about to receive) a PhD in protein biochemistry or similar field and must have published at least one first-author research article (papers in submission or on BioRxiv are also acceptable). Expertise in molecular biology, protein crystallography, computational biology/machine learning would be advantageous. An ability to work independently while taking feedback from others and interact well in a multi-disciplinary team environment is required.

https://www.jobs.cam.ac.uk/job/48291/