Department of Oncology

We are seeking a talented and enthusiastic computational biologist to join us in a project investigating the heterogeneity and evolutionally dynamics in Barrett's oesophagus and oesophageal adenocarcinoma using organoid models and other multi-omics phenotyping tools. This project, led by Dr John Lizhe Zhuang and Prof Rebecca Fitzgerald, is based at the Early Cancer Institute, University of Cambridge, at the Cambridge Biomedical Campus. The project is also a collaboration with Dr Jamie Blundell at the Early Cancer Institute, providing exciting opportunities to learn from experts in the field of in vitro organoid models, cancer biology and somatic evolution in cancer initiation and progression.

You will characterize a series of organoids derived from various disease stages including Barrett's oesophagus, dysplasia and oesophageal adenocarcinoma, and from multiple tissue sites. Using multi-omics data, including integrated RNA-seq, whole genome sequencing, and methylation analysis, you will investigate the models' biological representativeness, their lineage relatedness and how they respond to environmental cues, which will inform the phenotypic and genomic heterogeneity of the disease, and the evolutionary trajectory. This project has translational relevance for this poor outcome cancer.

https://www.jobs.cam.ac.uk/job/43452/