Cancer Research UK Cambridge Institute

We are seeking an ambitious and talented postdoctoral research associate to join our team at the CRUK Cambridge Institute (part of the University of Cambridge) to use comparative genomics to study the role of codon usage bias in gene regulation. This is an exciting opportunity to contribute to our goal of understanding gene regulation and genome organisation on an evolutionary timescale.

You will be part of a small team, led by Dr Susanne Bornelöv, which studies gene regulation using various approaches including machine learning, evolutionary genomics, and sequencing bioinformatics. Our team is funded by an 8-year Wellcome Career Development Award (https://wellcome.org/grant-funding/people-and-projects/grants-awarded/data-driven-methods-unravel-hidden-layers-genome).

Your project will use comparative genomics and transcriptomics to investigate the role of codon usage in gene regulation. You will lead the generation and analysis of sequencing data and carry out downstream bioinformatic analyses across a phylogeny of fruit flies. The ultimate goal is to understand how mRNA sequence contribute to mRNA stability and protein output, and how this shapes the genome over evolutionary time.

https://www.jobs.cam.ac.uk/job/46687/