Cambridge Centre for Research Associate (Computational) (Fixed Term)
Cancer Research UK Cambridge Institute
The Hannon laboratory at the CRUK Cambridge Institute (part of the University of Cambridge) is recruiting for a highly motivated and talented computational research associate to join a team of scientists studying the spatial architecture of triple-negative breast cancer (TNBC) and its response to treatment (funded by Wellcome Leap - https://wellcomeleap.org/)
This role will require interaction with a highly interdisciplinary team who have been responsible for some of the most prominent innovations and publications in the field. Greg Hannon is the lead investigator, with Co-Principal investigators Jean Abraham and John Marioni and co-investigators Jasmin Fisher, Dario Bressan, Menna Clatworthy, Walid Khaled, and Sam Aparicio.
Our Wellcome Leap Delta Tissue project aims to profile the tissue state of TNBC prior to, and after neo-adjuvant chemotherapy in responders and non-responders with the goal of creating a model to predict tissue end state from its initial state. Pushing the boundaries of what is currently possible with spatial proteomics, Wellcome Leap have further funded our team to build the world's largest spatial proteomics facility. The aim of this is to profile a similar number of protein markers in a single patient on a scale matching that currently achievable by spatial transcriptomics. This will involve translating spatial, to single-cell data, therefore experience in single-cell genomics is desirable.