Department of Biochemistry

A postdoctoral position is available for 14 months, in the first instance, to work with Professor Florian Hollfelder at the Department of Biochemistry: https://hollfelder.bioc.cam.ac.uk/

The objective of this project is to map 'fitness landscapes' for promiscuous enzymes (able to catalyse multiple, chemically distinct reactions), by analysis of experimental data (ultrahigh-throughput screening of libraries >10e6, analysed by deep sequencing) and interpretation using classical physical-organic/structural/mechanistic approaches. Adaptive walks in sequence space from one promiscuous activity to another will thus be described in unprecedented detail and interpreted using machine learning/AI approaches, to ultimately provide insight for future protein engineering.

https://www.jobs.cam.ac.uk/job/43354/