Wellcome Trust/Cancer Research UK Gurdon Institute

The Ahringer laboratory at the Gurdon Institute in the University of Cambridge is seeking a talented and motivated Senior Bioinformatician to join their research group. Our research aims to decipher the step-by-step genomic regulation that drives developmental programmes.

A single-celled totipotent zygote produces a multitude of different cell types, however, the genome regulation that drives development is poorly understood. We address this by combining single-nucleus multi-omic profiling with the known lineage of C. elegans, which enables determination of the locus-specific regulation of chromatin and gene expression across all trajectories from the zygote to the differentiated state (http://www.ahringer.group.gurdon.cam.ac.uk/).

You will investigate genomic regulatory mechanisms in close collaboration with experimental colleagues, using existing cutting-edge software or devising new methods to analyse single-nucleus profiling data as well as other types of genomic and transcriptomic data. You will lead computational projects, participate in research activities of the laboratory as a whole, and contribute to the supervision of students, providing an ideal opportunity to develop an independent scientific career.

https://www.jobs.cam.ac.uk/job/43613/